Study of association of serum protein electrophoretic pattern using helena electrophoresis and lipid pattern in nephrotic syndrome

A study of nephrotic syndrome in pediatric patients admitted in Gandhi and Niloufer hospital, Hyderabad, Andhra Pradesh, is presented here with special emphasis on serum protein levels and lipid profile. Out of the total cases, more than half were males with onset before 5 years of age. A definite significant inverse correlation existed between T. protein & triglycerides; albumin & triglycerides & also between VLDL & albumin. Hence hyperlipidemia may probably be due to proteinuria & hypoproteinemia (hypoalbuminemia). Since proteinuria is reported to control the synthesis of lipoproteins at genetic level, this has been attributed to increased synthesis & decreased clearance of lipoproteins mainly apolipoprotein (B). Although statistical difference exists, there is considerable overlap in protein excretion & hyperlipidemia. In conclusion, lipoprotein abnormalities in nephrotic syndrome are mainly due to loss of protein & are more atherogenic, so cause more morbidity than previously thought thus hyperlipidemia in nephrotic syndrome should be treated aggressively. Keyword: Hyperlipidemia, Hypoproteinemia, Nephrotic syndrome, Proteinuria.